（一）个人简介
夏小俊，中山大学肿瘤防治中心/华南肿瘤学国家重点实验室研究员、博士生导师。主要从事天然免疫和肿瘤免疫研究。博士毕业于美国得克萨斯大学MD安德森癌症中心，随后在贝勒医学院和休斯顿卫理会医院研究所从事博士后和讲师工作，2015年回国入职中山大学肿瘤医院开展独立研究工作。

（二） 研究方向

夏小俊课题组目前研究领域集中在天然免疫通路对于肿瘤微环境的调控机制，基于纳米载体和新型佐剂开发新型mRNA肿瘤疫苗，以及组合疗法干预肿瘤微环境增强免疫治疗效果（JCI, 2019；JITC, 2021; PNAS, 2021; Cancer Res, 2021）。实验室获得科技部，基金委和广东省珠江计划青年团队等多个项目资助，研究经费充足。课题组支持独立和合作研究，组内多位博士后获得国家自然科学基金青年项目资助。

（三） 代表性论文

(1) Wenjing Xiong^#, Wenzhuo He^#, et al., Smad4 deficiency promotes pancreatic cancer immunogenicity by activating cancer-autonomous DNA sensing signaling axis. Submitted to Advanced Science. In final revising. (2) Feifei Xu^#, Zining Wang^#, Hongxia Zhang, Jiemin Chen, Xiaojuan Wang, Lei Cui, Chunyuan Xie, Mengyun Li, Fang Wang, Penghui Zhou, Jinyun Liu, Peng Huang, Xiaodong Xia^*, Xiaojun Xia^*. Mevalonate blockade in cancer cells triggers CLEC9a+ dendritic cell-mediated antitumor immunity.  Cancer Res, 2021, Sep 1;81(17):4514-4528. doi: 10.1158/0008-5472.CAN-20-3977. Epub 2021 Jul 15. (#, co-first authorship, *, co-correspondence) (期刊论文)

(3) Zining Wang^#,*, Feifei Xu^#, Jie Hu, Hongxia Zhang, Lei Cui, Wenhua Lu, Wenzhuo He, Xiaojuan Wang, Mengyun Li, Huanling Zhang, Wenjing Xiong, Chunyuan Xie, Yongxiang Liu, Penghui Zhou, Jinyun Liu, Peng Huang, Xiaofeng Qin, Xiaojun Xia^*. Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity. J Immunother Cancer. 2021, May; 9(5): e002155. Doi: 10.1136/jitc-2020-002155. (#, co-first authorship, *, co-correspondence) (期刊论文)

(4) Hongxia Zhang^#, Xinru You^#, Xiaojuan Wang, Lei Cui, Zining Wang, Feifei Xu, Mengyun Li, Zhenggang Yang, Jinyun Liu, Peng Huang, Yang Kang, Jun Wu*, Xiaojun Xia*. Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling. PNAS. 2021, 2021, 2021 Feb 9;118(6):e2005191118. doi: 10.1073/pnas.2005191118. (期刊论文)

(5) Wang Z, Chen J, Hu J, Zhang H, Xu F, He W, Wang X, Li M, Lu W, Zeng G, Zhou P, Huang P, Chen S, Li W, Xia LP*, Xia X*. cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity. J Clin Invest. 2019 Aug 13;130. pii: 127471. doi: 10.1172/JCI127471. (期刊论文)

夏小俊课题组隶属中山大学肿瘤医院/华南肿瘤学国家重点实验室，招收免疫学、生物信息学、肿瘤学或纳米生物材料背景的博士生(即将取得博士学位或博士毕业三年内)入站博士后，年薪30万元起; 课题组经费充足，鼓励学科交叉合作，欢迎联系！