杨 弘，博士，中山大学肿瘤防治中心胸外科（国家临床重点胸外科）

主任医师，博士研究生导师，广东省食管癌研究所副所长，广东省杰出青年医学人才

学术任职

华南肿瘤学重点实验室独立PI

亚洲心胸外科协会（ASCVTS）会员

中国抗癌协会食管癌专业委员会委员

中国临床肿瘤学会(CSCO)青年专家委员会常务委员

广东省抗癌协会食管癌专业委员会副主任委员

广东省胸部肿瘤防治研究会靶向治疗专业委员会主任委员

广东省药学会第一届胸外科专家委员会副主任委员

临床经验

2020–至今 中山大学肿瘤防治中心 胸外科 主任医师

2019 - 2020年 香港威尔斯亲王医院 微创胸外科 Fellow（香港优才计划）

2014 –至今 中山大学肿瘤防治中心 胸外科 副主任医师

2009 - 2014年 中山大学肿瘤防治中心 胸外科 主治医师

2006 - 2009年 中山大学肿瘤防治中心 外科 专科培训医师

研究方向

擅长肺小结节、肺癌、食管癌以及贲门癌（胃食管交界癌）的诊断与综合治疗、微创腔镜外科及机器人手术治疗。对中晚食管癌的术前放化疗并手术，不可切除食管癌、肺癌新辅助治疗后手术等综合治疗模式及食管癌、肺癌系统淋巴结清扫拥有丰富的经验。主持国家自然科学基金项目、广东省科技计划项目等，拥有课题经费逾千万。入选中山大学肿瘤防治中心临床医学科学家培育项目。于国际上首先报导术中超声针对食管癌喉返神经旁淋巴结的诊断研究，获2011CSCO优秀论文二等奖，2016年中国肺癌精彩学术大赛卓越奖。2016年受邀于ESMO欧洲肿瘤学大会口头报告食管癌术前放化疗的NEOCRTEC5010研究。2017年获亚洲心胸外科大会颁发的Furuse Awards杰出研究贡献奖。近5年来，以第一/共一/通讯作者共发表SCI收录文章20篇，其中大于10分的8篇，论著单篇影响因子最高50.717分，总影响因子200多分。2018年以第一作者身份将NEOCRTEC5010阶段性成果发表于国际权威杂志Journal of Clinical Oncology，结果证实，术前放化疗并手术可延长局部晚期食管癌的总生存，将食管癌患者的中位生存期延长将近50%，奠定了“术前新辅助放化疗联合手术”治疗模式在国内外的地位。

发表论文：

1. Rui Chen#, Qianwen Liu#, Qiaoqiao Li#, Yujia Zhu#, Lei Zhao, Shiliang Liu, Baoqing Chen, Mengzhong Liu, Yonghong Hu, Ting Lin, Jibin Li, Jiyang Chen, Yingxin Lv, Jianhua Fu* , Mian Xi*, Hong Yang*.A phase II clinical trial of toripalimab combined with neoadjuvant chemoradiotherapy in locally advanced esophageal squamous cell carcinoma (NEOCRTEC1901).EClinicalMedicine. 2023-08-01;62:102118.

2. Jianye Yuan#, Zelin Weng#, Zihui Tan#, Kongjia Luo#, Jian Zhong, Xiuying Xie a,c Chunhua Qu, Xiaodan Lin Hong Yang*, Jing Wen*, Jianhua Fu*.Th1-involved immune infiltrates improve neoadjuvant chemoradiotherapy response of esophageal squamous cell carcinoma. Cancer Letters. 2023-01-28;553:215959.

3. Zihang Mai#, Jianye Yuan#, Hong Yang#, Shuogui Fang#, Xiuying Xie, Xinye Wang, Jiaxin Xie, Jing Wen*, Jianhua Fu*. Inactivation of Hippo pathway characterizes a poor-prognosis subtype of esophageal cancer. JCI Insight. 2022;7(16): e155218 IF:9.496

4. Jing Wen*, Shuogui Fang#, Yi Hu#, Mian Xi#, Zelin Weng, Chuqing Pan, Kongjia Luo, Yihong Ling, Renchun Lai, Xiuying Xie, Xiaodan Lin, Ting Lin, Jiyang Chen, Qianwen Liu*, Jianhua Fu*, and Hong Yang*. Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma. EBioMedicine .2022;86: 104371.

5. Hong Yang#, MD; Hui Liu#, MD; Yuping Chen#, MD; Chengchu Zhu#, MD; Wentao Fang#, MD; Zhentao Yu#, MD; Weimin Mao#, MD; Jiaqing Xiang#, MD; Yongtao Han#, MD; Zhijian Chen#, MD; Haihua Yang#, MD; Jiaming Wang#, MD; Qingsong Pang#, MD; Xiao Zheng#, MD;Huanjun Yang#, MD; Tao Li#, MD; Xu Zhang, MD; Qun Li, MD; Geng Wang, MD; Baofu Chen, MD; Teng Mao, MD; Min Kong, MD;Xufeng Guo, MD; Ting Lin, MD; Mengzhong Liu, MD; Jianhua Fu, MD, PhD Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma. JAMA Surgery., 2021,156(08): 721-729.IF: 16.681

6. Xufeng Guo #, Zhexin Wang#; Hong Yang#, Teng Mao#, Yuping Chen, Chengchu Zhu, Zhentao Yu, Yongtao Han, Weimin Mao, Jiaqing Xiang, Zhijian Chen, Hui Liu, Haihua Yang,Jiaming Wang, Qingsong Pang, Xiao Zheng , Huanjun Yang, Tao Li, Xu Zhang, Qun Li, Geng Wang, Ting Lin, Mengzhong Liu, Jianhua Fu*, Wentao Fang*. Impact of Lymph Node Dissection on Survival after Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma. Annals of Surgery. 2023-02-01;277(2):259-266.

7. Shiliang Liu#, Jing Wen#, Hong Yang#, Qiaoqiao Li#, Yuping Chen, Chengchu Zhu, Wentao Fang, Zhentao Yu, Weimin Mao, Jiaqing Xiang, Yongtao Han, Lei Zhao, Hui Liu, Yonghong Hu, Mengzhong Liu, Jianhua Fu*, Mian Xi*. Recurrence patterns after neoadjuvant chemoradiotherapy compared with surgery alone in oesophageal squamous cell carcinoma: results from the multicenter phase III trial NEOCRTEC5010.European Journal of Cancer. 2020-10-01;138:113-121.

8. Yan Huang, Yihuai Hu, , Yaobin Lin， Jianhua Fu, , Jiadi Wu, Caiyan Fang, Min Liu, and Yang Hong#.Evaluation of Fibrin Sealant in Prevention of Cervical Anastomotic Leakage After McKeown Esophagectomy: A Single Center, Retrospective Study. ANN SURG ONCOL. 2021-10-01;28(11):6390-6397. IF：4.339

9. Sha Zhou^#， Hong Yang^#, Jun Zhang^#， Juncheng Wang, Zhaohui Liang, Songran Liu, Yong Li, Yanpeng Pan, MD, Lei Zhao, MD,* and Mian Xi, MD*.Changes in Indoleamine 2,3-Dioxygenase 1 Expression and CD8D Tumor-Infifiltrating Lymphocytes after Neoadjuvant Chemoradiation Therapy and Prognostic Signifificance in Esophageal Squamous Cell Carcinoma. International Journal of Radiation Oncology Biol Phys.2020 Jan; 108(1)286-294. IF: 8.013

10. Hong Yang#, Hui Liu#, Yuping Chen#, Chengchu Zhu#, Wentao Fang#, Zhentao Yu#, Weimin Mao#, Jiaqing Xiang#,Yongtao Han#, Zhijian Chen#, Haihua Yang#, Jiaming Wang#, Qingsong Pang#, Xiao Zheng#, Huanjun Yang#, Tao Li#,Florian Lordick, Xavier Benoit D’Journo, Robert J. Cerfolio, Robert J. Korst, Nuria M. Novoa, Scott J. Swanson,Alessandro Brunelli, Mahmoud Ismail, Hiran C. Fernando, Xu Zhang, Qun Li, Geng Wang, Baofu Chen, TengMao, Min Kong, Xufeng Guo, Ting Lin, Mengzhong Liu, Jianhua Fu,Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial. J Clin Oncol. 2018 Sep;36 (27): 2796-2803. IF:50.717

11. Li L^#, Li JC^#, Yang H^#, Zhang X, Liu LL, Li Y, Zeng TT, Zhu YH, Li XD, Li Y, Xie D, Fu L, Guan XY*Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis.Proc Natl Acad Sci USA.2018Sep;115(38):E8948-E8957. IF:11.205

12. Yang YF^#, Zhang MF^#, Tian QH^#, Fu J, Yang X, Zhang CZ*, Yang H*.SPAG5 interacts with CEP55 and exerts oncogenic activities via PI3K/AKT pathway in hepatocellular carcinoma.Mol Cancer.2018 Aug;17(1):117. IF:27.401

13. Wen Jing^#, Hu Yi^#, Liu Qianwen^#,Ling Yihong, Zhang Shuishen, Luo Kongjia, Xie Xiuying, Fu Jianhua*, Yang Hong*.miR-424 coordinates multilayered regulation of cell cycle progression to promote esophageal squamous cell carcinoma cell proliferation.EBioMedicine.2018Nov;37:110-124. IF:8.143

14. Lei Li^#, Hong Yang^#, Yan Li1, Xiao-Dong Li, TingTing Zeng, Su-Xia Lin, Ying-Hui Zhu* and XinYuan Guan*.Hypoxia restrains the expression ofcomplement component 9 in tumorassociated macrop-hages promotingnon small cell lungcancer progression.Cell Death Discovery.2018;4 (63):2-12. IF:5.241

15. Jianwei Wang #, Min Liu #, Jingxian Shen# , Haichao Ouyang #, Xiuying Xie#, Ting Lin#, Anhua Li*and Hong Yang *.Diagnostic value of intraoperative ultrasonography in assessing thoracic recurrent laryngeal nerve lymph nodes in patients with esophageal cancer.BMC Cancer. 2018 July;18(1):737. IF:4.43

16. Jing-Sheng Zeng, Zhen-Dong Zhang, Li Pei, Zhi-Zhu Bai, Yong Yang, Hong Yang*,Qiu-Hong Tian*.CBX4 exhibits oncogenic activities in breast cancer via Notch1 signaling.Int J Biochem Cell Biol. 2018 Feb;95:1-8. IF:5.058

17. Bo Qiu#, JiaXiang Li# , Bin Wang# , ZhiQiang Wang, Ying Liang , Peiqiang Cai, ZhaoLin Chen , MengZhong Liu, JianHua Fu， Hong Yang*, Hui Liu*.Adjuvant Therapy for a Microscopically Incomplete Resection Margin after an Esophagectomy for Esophageal Squamous Cell Carcinoma.J Cancer.2017 Jan;8(2):249-257. IF:4.207

18. Liu M#, Hu Y#, Zhang MF#, Luo KJ, Xie XY, Wen J, Fu JH, Yang H*.MMP1 promotes tumor growth and metastasis in esophageal squamous cell carcinoma.Cancer Lett.2016 July;377(1):97-104. IF:8.679

Bo Qiu#, De Ling Wang#, Hong Yang#, Wei Hao Xie, Ying Liang, Pei qiang Cai ZhaoLin

1. Chen, Meng Zhong Liu, JianHua Fu, Chuan Miao Xie*, Hui Liu*Combined modalities of magnetic resonance imaging, endoscopy and computed tomography in the evaluation of tumor responses to definitive chemoradiotherapy in esophageal squamous cell carcinoma. Radiotherapy and Oncology. 2016 Nov;121(2):239-245. IF: 6.28

2. Song Ran Liu#, Bo Qiu#, Hong Yang#, Ying Liang, Fang Wang, Shi Liang Liu, Zhao Lin Chen, Li Zhang, Meng Zhong Liu, Si Yu Wang, Lan Feng Lin*, and Hui Liu*.Epidermal Growth Factor Receptor Mutation Status and Treatment Outcome for R0-Resected Patients with Stage 3 Non-small Cell Lung Cancer.Ann Surg Oncol. 2016 Jan;23(6):2115-22. IF:5.344

3. Liu SL#, Yang H#, Zhang P#, Zhang L, Zhao L, Luo LL, Fu JH, Liu MZ, Xi M*.Neoadjuvant chemoradiotherapy with cisplatin plus vinorelbine versus cisplatin plus fluorouracil for esophageal squamous cell carcinoma: A matched case-control study. Radiotherapy and Oncology. 2016;121(2):239~245. IF:6.28

4. Huang QY#, Luo KJ#, Yang H#, Wen J, Zhang SS, Li JH, Bella AE, Liu QW, Yang F, Zheng YZ, Hu RG,Chen JY, Fu JH*. Impact of alcohol consumption on survival in patients with esophageal carcinoma:a large cohort with long-term follow-up.Cancer Sci. 2014;105(12):1638-1646. IF:6.419

5. Wen J#, Yang H#, Liu MZ#, Luo KJ, Liu H, Hu Y, Zhang X, Lai RC, Lin T, Wang HY, Fu JH*.Gene expression analysis of pretreatment biopsies predicts the pathological response of esophageal squamous cell carcinomas to neo-chemoradiotherapy.Ann Oncol.2014;25（9）:1769~1774. IF:32.924

6. Zhang SS#, Yang H#, Luo KJ#, Huang QY, Chen JY, Yang F, Cai XL, Xie X, Liu QW, Bella AE, Hu RG, Wen J, Hu Y, Fu JH(*).The impact of body mass index on complication and survival in resected oesophageal cancer: a clinical-based cohort and meta-analysis.Br J Cancer.2013;109(11)：2894~2903. IF:7.64

国内期刊

1. 杨弘，傅剑华，刘孟忠，等. 术前放化疗并手术治疗局部晚期食管鳞癌的多中心随机对照临床研究. 中华医学杂志, 2012,92(15):1028-1033.

2. 杨弘，傅剑华，胡祎,等. 术前放化疗并手术治疗局部晚期食管癌。 中华医学杂志，2008, 88（45）:3182－3185.

3. 杨弘,，傅剑华，胡祎，等. 生存素表达与肺癌多药耐药株H460/cDDP化疗敏 感性的关系. 中华医学杂志, 2007, 87(27):1934-7.

4. 杨弘，傅剑华，胡袆，等. 食管贲门癌切除消化道重建术后胃狭窄. 中华胃肠外科杂志,2006,9(1):38-40.

更新日期：2023年8月23日