个人简介：肿瘤遗传学博士，中组部“千人计划”国家特聘专家，亚盛医药董事长，兼任中山大学肿瘤防治中心教授及博导、中国药科大学产业教授、中国药促会研发专委会副主任委员等职。于2009年共同创办亚盛医药，并在细胞凋亡及自噬双通道调节新靶点药物开发领域内取得重大突破，成功将9项具有全球范围内“First-in-class”或“Best-in-class”类潜力原创新药推进到中国、美国、澳大利亚三地临床开发阶段。先后承担国家“863”专项、重大新药创制专项等重大科研攻关项目近10项。课题组近五年来获得了国家自然基金、广东省重大新药创制重大科技专项基金，以及广州市健康医疗协同创新重大专项基金等支持，在Theranostics、J Exp Clin Canc Res等国际知名SCI杂志发表论文十余篇,先后发表学术论文及摘要100多篇，有20多项国内外发明专利。2022年原创并推动中国首个携T315I突变耐药慢粒白血病用药上市(奥雷巴替尼·耐立克入选国内十大新药)，填补治疗空白。

研究方向：专注肿瘤学、细胞凋亡机理与新药研发

获奖情况：

1. 2023年荣膺第十六届“谈家桢生命科学产业化奖”

2. 荣获 2018 独墅湖杯“最具影响力药物研发领军人物奖”

代表性研究成果：

1. Qiu-Yun Luo# , Tian Di# , Zhi-Gang Chen# , Jian-Hong Peng , Jian Sun , Zeng-Fei Xia, Wen-Tao Pan , Fan Luo, Fei-Teng Lu , Yu-Ting Sun , Li-Qiong Yang , Lin Zhang*, Miao-Zhen Qiu*, Da-Jun Yang*. Novel prognostic model predicts overall survival in colon cancer based on RNA splicing regulation gene expression. Cancer Science. 2022 Oct;113(10):3330-3346.

2. Qiu-Yun Luo #, Tian Di # , Miao-Zhen Qiu # , Zeng-Fei Xia , Yong Du , Run-Duan Lin , Li-Qiong Yang, Yu-Ting Sun, Da-Jun Yang* , Jian Sun* , Lin Zhang* .High AKAP8L expression predicts poor prognosis in esophageal squamous cell carcinoma.Cancer Cell International.2022 Feb 21;22(1):90.

3. Fan Luo#,Fei-Teng Lu#, Miao-Zhen Qiu#,Ting Zhou; Wen-Juan Ma,Min Luo, Kang-Mei Zeng,Qiu-Yun Luo,Wen-Tao Pan, Lin Zhang,Zeng-Fei Xia,Zhong-Han Zhang, Jia-Xin Cao, Hong-Yun Zhao, Li Zhang*and Da-Jun Yang* .Gemcitabine and APG-1252, a novel small molecule inhibitor of BCL-2/BCL-XL, display a synergistic antitumor effect in nasopharyngeal carcinoma through the JAK-2/STAT3/MCL-1 signaling pathway 。Cell Death &Disease 2021 Aug; 12(8): 772.

4. Douglas D. Fang# ,Qiuqiong Tang,#,Yanhui Kong, Qixin Wang,Jiaxing Gu, Xu Fang, Peng Zou, Tao Rong,Jingwen Wang, Dajun Yang*and Yifan Zhai* .MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment。 Journal For Immunotherapy Of Cancer. 2019; 7: 327.

5. Jiao Ji# , Yan Yu#, ZhiLing Li# , MingYuan Chen, Rong Deng, Xiang Huang,GuangFeng Wang,MengXia Zhang,Qi Yang,Senthilkumar Ravichandran, GongKan Feng, XueLian Xu, ChenLu Yang,MiaoZhen Qiu,Lin Jiao, Dajun Yang*,XiaoFeng Zhu* .XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells, Theranostics, 2018.2.5, 8(6): 1494~1510.