个人简介
中山大学肿瘤防治中心研究员，博士生导师
国家自然科学基金优秀青年基金、中山大学百人计划、全国优秀博士论文提名、中科院优博获得者
美国MD安德森癌症中心 博士后、讲师 （2015）
美国耶鲁大学 博士后 （2009）
中科院上海生命科学院 理学博士（2007）
南京大学 理学学士（2002）
研究方向
1. 病毒感染相关肿瘤的遗传易感性
2. EB病毒与宿主的相互作用
3. 以EB病毒为靶点的抗肿瘤药物研发
代表性论文
Xiang T, Lin YX, Ma W, Zhang HJ, Chen KM, He GP, Zhang X, Xu M, Feng QS, Chen MY, Zeng MS, Zeng YX, Feng L.Vasculogenic mimicry formation in EBV-associated epithelial malignancies. Nat Commun. 2018 Nov 27;9(1):5009.
Deng C, Lin YX, Qi XK, He GP, Zhang Y, Zhang HJ, Xu M, Feng QS, Bei JX, Zeng YX, Feng L. TNFRSF19 inhibits TGFβ signaling through interaction with TGFβ receptor type I to promote tumorigenesis. Cancer Res. 2018 Jul 1;78(13):3469-3483
Zhang HJ, Tian JX, Qi XK, Xiang T, He GP, Zhang H, Yu X, Zhang X, Zhao B, Feng QS, Chen MY, Zeng MS, Zeng YX, Feng L. Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation. PLoS Pathog. 2018 Jul 27;14(7):e1007208
Qi XK, Han HQ, Zhang HJ, Xu M, Li L, Chen L, Xiang T, Feng QS, Kang T, Qian CN, Cai MY, Tao Q, Zeng YX, Feng L. OVOL2 links stemness and metastasis via fine-tuning epithelial-mesenchymal transition in nasopharyngeal carcinoma. Theranostics 2018 Mar 8;8(8):2202-2216. (Editorial Theranostics. 2018 Mar 8;8(8):2242-2244.)
Li N, Yang L, Qi XK, Lin YX, Xie X, He GP, Feng QS, Liu LR, Xie X, Zeng YX, Feng L. BET bromodomain inhibitor JQ1 preferentially suppresses EBV-positive nasopharyngeal carcinoma cells partially through repressing c-Myc. Cell Death Dis. 2018 Jul 9;9(7):761
Yuan J, Chen L, Xiao J, Qi XK, Zhang J, Li X, Wang Z, Lian YF, Xiang T, Zhang Y, Chen MY, Bei JX, Zeng YX, Feng L. SHROOM2 inhibits tumor metastasis through RhoA-ROCK pathway dependent and independent mechanisms in nasopharyngeal carcinoma. Cell Death Dis. 2019 Jan 25;10(2):58
Li N#, Feng L#, Han HQ, Yuan J, Qi XK, Lian YF, Kuang BH, Zhang YC, Deng CC, Zhang HJ, Yao YY, Xu M, He GP, Zhao BC, Gao L, Feng QS, Chen LZ, Yang L, Yang D*, Zeng YX*.A novel Smac mimetic APG-1387 demonstrates potent antitumor activity in nasopharyngeal carcinoma cells by inducing apoptosis. Cancer Lett. 2016 Jul 15;381(1):14-22 (Commentaries in Faculty of 1000)
Lian YF, Yuan J, Cui Q, Feng QS, Xu M, Bei JX, Zeng YX, Feng L.Upregulation of KLHDC4 Predicts a Poor Prognosis in Human Nasopharyngeal Carcinoma. PLoS One. 2016 Mar 31;11(3):e0152820.
Feng L, Wang J, Li N, Li Y, Gao M, Wang W and Chen J. Cell cycle-dependent inhibition of 53BP1 by BRCA1. Cell Discov. 2015 Aug 4;1:15019.
Feng L, Fong KW, Wang J, Wang W, Chen J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem. 2013 Apr 19; 288(16):11135-43.
Feng L, Chen J. The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol. 2012 Jan 22;19(2):201-6
Feng L, Wang J, Chen J. The Lys 63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. J Biol Chem. 2010 Oct 1; 285(40):30982-8. (Commentaries in Faculty of 1000)
Feng L, Huang J, Chen J. MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev. 2009 Mar 15; 23(6):719-28.
Feng L, Xie X, Ding Q, Luo X, He J, Fan F, Liu W, Wang Z, Chen, Y. Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci USA. 2007 Sep 4;104(36):14348-53.
更新时间：2023年1月9日
